Faculty Publications

Vyacheslav Palchevskiy, PhD

Publications

Hoffmann-Vold A.M., Weigt S.S., Saggar R., Palchevskiy, V., Volkmann, E.R., Liang, L.L., Ross, D., Ardehali, A., Lynch, J.P., Belperio, J.A.. (2019). Endotype-phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease. EBioMedicine. 50:379-386. PMID:31732480

Weigt, S.S., Wang, X., Palchevskiy, V., Li, X., Patel, N., Ross, D.J., Reynolds, J., Shah, P.D., Danziger-Isakov, L.A., Sweet, S.C., Singer, L.G., Budev, M., Palmer, S., Belperio, J.A. (2019). Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection. The Journal of Heart and Lung Transplantation. 38(8):845-855. PMID: 31122726.

Palchevskiy, V, Xue, Y.Y., Kern, R., Weigt, S.S., Gregson, A.L., Song, S.X., Fishbein, M.C., Hogaboam, C.M., Sayah, D.M., Lynch, J.P., Keane, M.P., Brooks, D.G., Belperio, J.A. (2019). CCR4 expression on host T cells is a driver for alloreactive responses and lung rejection. JCI Insight. 4(12):e121782

Hoffmann-Vold, A.M., Weigt, S.S., Palchevskiy, V., Volkmann, E., Saggar, R., Li, N., Midtvedt, Ø., Lund, M.B., Garen, T., Fishbein, M.C., Ardehali, A., Ross, D.J., Ueland, T., Aukrust, P., Lynch, J.P., Elashoff, R.M., Molberg, Ø., Belperio, J.A. (2018). Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis. PLoS One. 13(11):e0206545. doi: 10.1371/journal.pone.0206545. PMCID: PMC6245508

Weigt, S.S., Wang, X., Palchevskiy, V., Patel, N., Derhovanessian, A., Shino, M.Y., Sayah, D.M., Lynch, J.P., Saggar, R., Ross, D.J., Kubak, B.M., Ardehali A, Palmer S, Husain S, Belperio JA. (2018). Gene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung Allograft. Transplantation. 102(6):986-993. PMID: 29256975

Hoffmann-Vold AM, Hesselstrand R, Fretheim H, Ueland T, Andreassen AK, Brunborg C, Palchevskiy V, Midtvedt Ø, Garen T, Aukrust P, Belperio JA, Molberg Ø. (2018). CCL21 as a potential serum biomarker for pulmonary arterial hypertension in Systemic Sclerosis. Arthritis Rheumatol. doi: 10.1002/art.40534. [Epub ahead of print].

Weigt SS, Wang X, Palchevskiy V, Patel N, Derhovanessian A, Shino MY, Sayah DM, Lynch JP 3rd, Saggar R, Ross DJ, Kubak BM, Ardehali A, Palmer S, Husain S, Belperio JA. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung Allograft. Transplantation. doi: 10.1097/TP.0000000000002058. [Epub ahead of print].

Shino MY, Weigt SS, Li N, Palchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Huynh RH, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. (2017). The prognostic importance of CXCR3 chemokine during organizing pneumonia on the risk of chronic lung allograft dysfunction after lung transplantation. PLoS One. 12(7):e0180281. doi: 10.1371/journal.pone.0180281. eCollection 2017

Weigt SS, Palchevskiy V, Belperio JA. (2017). Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction. J Clin Invest. 127(6), 2022-2029. doi: 10.1172/JCI93537.

Weigt SS, Wang X, Palchevskiy V, Gregson AL, Patel N, DerHovanessian A, Shino MY, Sayah DM, Birjandi S, Lynch JP 3rd, Saggar R, Ardehali A, Ross DJ, Palmer SM, Elashoff D, Belperio JA. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. PLoS One. 12(1):e0169894. doi: 10.1371/journal.pone.0169894.

Birjandi SZ, Palchevskiy V, Xue YY, Nunez S, Kern R, Weigt SS, Lynch JP 3rd, Chatila TA, Belperio JA. (2016). CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis. Am J Pathol, 186(8), 2008-20. doi: 10.1016/j.ajpath.2016.03.020.

DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP 3rd, Elashoff RM, Belperio JA. (2015). The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant, 16(2), 640-9. doi: 10.1111/ajt.13475

Gregson AL, Hoji A, Injean P, Poynter ST, Briones C, Palchevskiy V, Weigt SS, Shino M, Derhovanessian A, Sayah D, Saggar R, Ross D, Ardehali A, Lynch Iii JP, Belperio JA. (2015). Altered Exosomal RNA Profiles in Bronchoalveolar Lavage from Lung Transplants with Acute Rejection. Am J Respir Crit Care Med, 192(12), 1490-503. doi: 10.1164/rccm.201503-0558OC

Shino MY, Weigt SS, Li N, Palchevskiy V, Derhovanessian A, Saggar R, Sayah DM, Gregson AL, Fishbein MC, Ardehali A, Ross DJ, Lynch JP 3rd, Elashoff RM, Belperio JA. (2013).  CXCR3 ligands are associated with the continuum of diffuse alveolar damage to chronic lung allograft dysfunction. Am J Respir Crit Care Med, 188(9), 1117-25. doi: 10.1164/rccm.201305-0861OC

Gregson AL, Wang X, Weigt SS, Palchevskiy V, Lynch JP 3rd, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA. (2013). Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation. Am J Respir Crit Care Med, 187(5), 518-26. doi: 10.1164/rccm.201207-1228OC

Weigt SS, Derhovanessian A, Liao E, Hu S, Gregson AL, Kubak BM, Saggar R, Saggar R, Palchevskiy V, Fishbein MC, Lynch JP 3rd, Ardehali A, Ross DJ, Wang HJ, Elashoff RM, Belperio JA. (2012). CXCR3 chemokine ligands during respiratory viral infections predict lung allograft dysfunction. Am J Transplant, 12(2), 477-84.

Abstracts

S. Weigt, X. Wang, V. Palchevskiy, N. D. Patel, D. J. Ross, Y. M. Shino, J. M. Reynolds, P. Shah, L. G. Singer, M. M. Budev, S. M. Palmer, J. A. Belperio. (2018). Gene Expression Profiling of BAL Cells and PBMC During Lung Allograft Acute Cellular Rejection. American Journal of Respiratory and Critical Care Medicine. 197:A4740

A.-M. Hoffmann-Vold, H. Didriksen, H. Fretheim, E. Gude, V. Palchevskiy, T. Garen, Ø. Midtvedt, A. Andreassen, J. Belperio ,Ø.Molberg. (2018). FRI0431 Dysregulation of lymphangiogenetic factors in systemic sclerosis patients with pulmonary arterial hypertension. Annals of the Rheumatic Diseases. 77:745-746.

Huynh, R. Saggar, N. Li, V. Palchevskiy, N. Patel, Y. Xue, R. Kern, R. Saggar, J. P. Lynch 3rd, D. J. Ross, R. Elashoff,R. H. Huynh S. Weigt, J. A. Belperio (2017). Elevated Baseline Concentrations Of Cxcl-9 And -10 Are Associated With Irreversible Vascular Remodeling Of The Pulmonary Circulation In Portopulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine. 195:A4230

S.S. Weigt, X. Wang, V. Palchevskiy, N. Patel, A. DerHovanessian, M.Y. Shino, D. Sayah, A.L. Gregson, J.P. Lynch III, R. Saggar, D.J. Ross, A. Ardehali, D. Elashoff, J.A. Belperio. (2017). Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc. 3, S252. doi: 10.1513/AnnalsATS.201608-618MG

A. DerHovanessian, V. Palchevskiy, S. Weigt, M. Shino, A. Gregson, D. Sayah, J. P. Lynch, R. Saggar, D. Ross, A. Ardehali, R. M. Elashoff, J. A. Belperio. (2016). The Role Of Hyaluronan-CD44 Biology During Primary Graft Dysfunction In Lung Transplant Recipients. Am J Respir Crit Care Med. 193, A3452.

S.S. Weigt, X. Wang, V. Palchevskiy, N. Patel, A. DerHovanessian, M.Y. Shino, D. Sayah, A.L. Gregson, J.P. Lynch III, R. Saggar, D.J. Ross, A. Ardehali, D. Elashoff, J.A. Belperio. (2016) Gene Expression Profiling of Bronchoalveolar Lavage Cells during Aspergillus Colonization of the Lung Allograft. Journal of Heart and Lung transplantation. 35(4), S312.

A.-M. Hoffmann-Vold, R. Huynh, E. Volkmann, V. Palchevskiy, Ø. Midtvedt, T. Garen, A. Der Hovanessian, S. Weigt, M. Fishbein, A. Ardehali, D. Ross, R. Saggar, J. Lynch, P. Aukrust, T. Ueland, R. Elashoff, Ø. Molberg, J. Belperio. (2016). Augmented Concentrations of Cx3cl1 Are Associated with Progressive Interstitial Lung Disease in Systemic Sclerosis. Ann Rheum Dis. 2016;75:527 doi:10.1136/annrheumdis-2016-eular.4406

R. Huynh, R. Saggar, N. Li, R. Elashoff, E. Volkmann, R. Saggar, A. Derhovanessian, D. Ross, M. Fishbein, J. Lynch, V. Palchevskiy, S. Weigt, J. Belperio. (2015). Increased Concentrations of CCL5, PDF-AA and PDGF-BB are Associated with Irreversible Vascular Remodeling of the Pulmonary Circulation in Interstitial Lung Disease Associated Pulmonary Arterial Hypertension. Ann Rheum Dis.74, 654-655. doi:10.1136/annrheumdis-2015-eular.2098

R. Huynh, M. Y. Shino, A. Derhovanessian, D. M. Sayah, R. Saggar, V. Palchevskiy, A. Ardehali, D. J. Ross, J. P. Lynch, S. Weigt, J. A. Belperio. (2015). Th2 Products IL-4 And IL-13 Are Associated With Rapidly Progressive Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 191, A2166

A Der Hovanessian, V Palchevskiy, SS Weigt, MY Shino, AL Gregson, BM Kubak, JP Lynch, R Saggar, DJ Ross, A Ardehali, R. Elashoff and JA Belperio. (2013). The CCL2/CCR2 Axis in Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome Following Lung Transplantation. The Journal of Heart and Lung Transplantation. 32(4), S28–S29.